Water → HCID 178512607、化合物

HRID 236647

反応式

HRID 236647 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[CH:10][C:5]=1[C:6](=O)[CH2:7]Br)([O-:3])=[O:2].[C:14]([NH:17][C:18]([NH2:20])=[S:19])(=[NH:16])[NH2:15].O.[OH-].[Na+]>CN(C)C=O>[NH:17]([C:18]1[S:19][CH:7]=[C:6]([C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[N+:1]([O-:3])=[O:2])[N:20]=1)[C:14]([NH2:16])=[NH:15]

参加物

6

反応物 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 2440252-Bromo-2'-nitroacetophenoneHCID 178513045HCID 178513045、化合物

生成物 1

HCID 178512607HCID 178512607、化合物収率 95%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 16.5 gm of 2-nitro-phenacyl bromide and 7.98 gm of amidinothiourea in 70 ml of dimethylformamide was stirred at room temperature for 16 hours, and then poured into 350 ml of water. The solution was made alkaline with 10% sodium hydroxide, and the solid which separated out after cooling was filtered, washed with water and dried, yielding 16.9 gm of the title compound, m.p. 176°-178° C.

後処理

  1. customthe solid which separated out
  2. temperatureafter cooling
  3. filtrationwas filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-0999f81bbcdc4f8fac59951338ee04e7
出典データセット
uspto-grants-1987_02
特許番号
US04645841

関連ノート

読み込み中…