Hydrogen Bromide → (6-Bromopyridin-2-yl)(1-methylpiperidin-4-yl)methanone hydrobromide

反応式

C(N(CC)[C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]1)=[O:5])C.[Br:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([Br:22])[N:17]=1.Br>>[BrH:15].[Br:22][C:18]1[N:17]=[C:16]([C:4]([CH:6]2[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]2)=[O:5])[CH:21]=[CH:20][CH:19]=1

参加物

反応物 3

HCID 260Hydrogen Bromide

HCID 122742,6-Dibromopyridine

HCID 412858N,N-diethyl-1-methylpiperidine-4-carboxamide

生成物 1

HCID 86679073(6-Bromopyridin-2-yl)(1-methylpiperidin-4-yl)methanone hydrobromide

実験手順

reacting N,N-diethyl-1-methylpiperidine-4-carboxamide with a solution of 2,6-dibromopyridine and Grignard reagent followed by hydrobromic acid to yield (6-bromopyridin-2-yl)(1-methylpiperidin-4-yl)methanone hydrobromide;

出典と根拠

ORDレコード: ord-53e29b5148414edc8c5585f4e59b8749
出典データセット: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08697876B2

反応ノート

読み込み中…