1,1'-Carbonyldiimidazole → 6-bromo-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][NH2:9])=[N:6][CH:7]=1.[C:10](N1C=CN=C1)(N1C=CN=C1)=[O:11]>C(#N)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:10](=[O:11])[NH:9][N:8]=2)[CH:7]=1参加物
4
実験手順
A suspension of 40 g 5-bromo-2-hydrazinylpyridine (212 mmol) and 38 g 1,1′-Carbonyldiimidazole (234 mmol) in 500 mL acetonitrile was refluxed for 2 h. The reaction was then cooled to room temperature overnight. The precipitate was collect by filtration. 6-Bromo-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one as a light brown solid was collected. m/z (ESI)=213.9 [M+H]+. 1H NMR (δ, d6-DMSO, 400 MHz) 12.59 (s, 1H), 8.04 (dd, 1H), 7.21 (m, 2H).
後処理
- temperaturewas refluxed for 2 h
- filtrationThe precipitate was collect by filtration
- custom6-Bromo-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one as a light brown solid was collected
出典と根拠
- ORDレコード
- ord-4564263c04f6480598dca5d81065fc7b
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08703759B2
反応ノート
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