4-Fluoroaniline → HCID 178466974、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]([O:15]CC)=O)=[C:11]([CH3:18])[N:10]=[C:9]2[SH:19])=[CH:4][CH:3]=1.F[C:21]1C=CC(N)=CC=1.ClC(C(=O)C)C(=O)C.[S-]C#N.[K+]>C(#N)C.C(O)(=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([C:13](=[O:15])[CH3:21])=[C:11]([CH3:18])[N:10]=[C:9]2[SH:19])=[CH:6][CH:7]=1参加物
7
実験手順
1-(1-(4-Fluorophenyl)-2-mercapto-4-methyl-1H-imidazol-5-yl)ethanone (60) was prepared in a similar manner as that described for the synthesis of compound 57 using 4-fluoroaniline (2 g, 18 mmol), 3-chloropentane-2,4-dione (2.7 g, 19.8 mmol), potassium thiocyanate (3.5 g, 36 mmol) and acetic acid (10 mL) in acetonitrile (100 mL).
出典と根拠
- ORDレコード
- ord-cc6532f8fcd74d3f9335fc51257a3111
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08703776B2
反応ノート
読み込み中…