Lithium Hydroxide → 2-(((2,6-Dichlorophenyl)thio)methyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylic acid

HRID 2368525ノート

反応式

HRID 2368525 の反応式
CN1C=C(CN(C)C(C2N(C3C=CC(F)=CC=3)C(S)=NC=2)=O)C(C)=N1.[Cl:26][C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([Cl:33])[C:28]=1[S:34][CH2:35][C:36]1[N:37]([C:46]2[CH:51]=[CH:50][C:49]([F:52])=[CH:48][CH:47]=2)[C:38]([C:41]([O:43]CC)=[O:42])=[CH:39][N:40]=1.[OH-].[Li+].C1COCC1>O.CO>[Cl:26][C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([Cl:33])[C:28]=1[S:34][CH2:35][C:36]1[N:37]([C:46]2[CH:51]=[CH:50][C:49]([F:52])=[CH:48][CH:47]=2)[C:38]([C:41]([OH:43])=[O:42])=[CH:39][N:40]=1

参加物

7

反応物 4

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 71117764ethyl 2-(((2,6-dichlorophenyl)thio)methyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylateHCID 178434002N-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-2-mercapto-N-methyl-1H-imidazole-5-carboxamide

生成物 1

HCID 711173752-(((2,6-Dichlorophenyl)thio)methyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

2-(((2,6-Dichlorophenyl)thio)methyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylic acid (73) was prepared in a similar manner as that described for the synthesis of compound 7 using ethyl 2-(((2,6-dichlorophenyl)thio)methyl)-1-(4-fluorophenyl)-1H-imidazole-5-carboxylate (72) (1.5 g, 3.5 mmol), lithium hydroxide (1.6 g, 40 mmol), THF (50 mL), methanol (50 mL), and water (20 mL).

出典と根拠

ORDレコード
ord-6d14e2e0a4c04b47a3d3acf94cf44521
出典データセット
uspto-grants-2014_04
特許番号
US08703776B2

反応ノート

読み込み中…