Formaldehyde → 4-fluoro-2-methylamino-benzoic Acid
反応式
[F:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5](=[CH:9][CH:10]=1)[C:6]([OH:8])=[O:7].[CH2:12]=O.[H][H]>[Pd].C(O)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([NH:11][CH3:12])[C:5](=[CH:9][CH:10]=1)[C:6]([OH:8])=[O:7]参加物
6
実験手順
A mixture of 4-fluoroanthranilic acid (2 g), aqueous formaldehyde (37-40% w/v; 6.5 ml) and palladium on charcoal (1 g of 5%) in acetic acid (70 ml) was hydrogenated over 18 hours during which 570 ml hydrogen was taken up. The mixture was filtered, evaporated under reduced pressure and the residue recrystallised from toluene to give 4-fluoro-N-methylanthranilic acid, m.p. 180°-181°. (Compound 7)
後処理
- filtrationThe mixture was filtered
- customevaporated under reduced pressure
- customthe residue recrystallised from toluene
出典と根拠
- ORDレコード
- ord-1e368b4ec70a43808068c05308364994
- 出典データセット
- uspto-grants-1992_03
- 特許番号
- US05093364
反応ノート
読み込み中…