Water → ethyl N-(2-fluorophenyl)carbamate

HRID 2372173ノート

反応式

HRID 2372173 の反応式
[F:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].Cl[C:10]([O:12][CH2:13][CH3:14])=[O:11].[OH-].[Na+].O>CCOCC>[F:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:10](=[O:11])[O:12][CH2:13][CH3:14]

参加物

6

反応物 4

HCID 962WaterHCID 95842-FluoroanilineHCID 10928Ethyl chloroformate2 回HCID 14798Sodium Hydroxide

生成物 1

HCID 242730ethyl N-(2-fluorophenyl)carbamate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

To a solution of 2-fluoroaniline (11.1 g, 100.0 mmol) in 100 ml of dry ether cooled in an ice bath is added ethyl chloroformate (7.1 ml, 8.1 g, 75.0 mmol). After addition, the mixture is allowed to warm to RT and is stirred at RT for 3 hours. Then a 10% sodium hydroxide solution (54 ml, 2.8M, 150.0 mmol) is added, followed by another 7.1 ml of ethyl chloroformate. The mixture is stirred at RT for 3 hours, and is then poured into water and ether. The organic layer is separated, washed with 5% HCl and with brine, and dried. The solvent is removed to give ethyl N-(2-fluorophenyl)carbamate.

後処理

  1. additionAfter addition
  2. stirringThe mixture is stirred at RT for 3 hours
  3. customThe organic layer is separated
  4. washwashed with 5% HCl and with brine
  5. customdried
  6. customThe solvent is removed

出典と根拠

ORDレコード
ord-1066a7ddc5ef453cb27af5ee19be46b2
出典データセット
uspto-grants-1992_03
特許番号
US05098462

反応ノート

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