1-Propanol → 5-(4-(benzyloxy)phenyl)-3-(2-cyanoethyl)-1,3,4-oxadiazol-2(3H)-one

HRID 2372811ノート

反応式

HRID 2372811 の反応式
[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([NH:15][NH2:16])=[O:14])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19](#[N:22])[CH:20]=[CH2:21].[CH2:23]([OH:26])CC>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]2[O:14][C:23](=[O:26])[N:16]([CH2:21][CH2:20][C:19]#[N:22])[N:15]=2)=[CH:17][CH:18]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 3

HCID 10311-PropanolHCID 7855Acrylonitrile2 回HCID 15264864-(Benzyloxy)benzohydrazide

生成物 1

HCID 30358125-(4-(benzyloxy)phenyl)-3-(2-cyanoethyl)-1,3,4-oxadiazol-2(3H)-one収率 88%

実験手順

To a solution of 100 mmoles of (4-benzyloxy benzoyl) hydrazine in 200 ml of 1-propanol, 100 mmoles of acrylonitrile are added and the mixture is heated for 24 hours at reflux. Then 50 mmoles of acrylonitrile are added and the heating is continued at reflux for 24 hours. After cooling, the product is filtered and crystallized in a water-ethanol mixture and 26 g (yield: 88%) of the expected product were obtained.

後処理

  1. temperaturethe mixture is heated for 24 hours
  2. temperatureat reflux
  3. temperatureat reflux for 24 hours
  4. temperatureAfter cooling
  5. filtrationthe product is filtered
  6. customcrystallized in a water-ethanol mixture

出典と根拠

ORDレコード
ord-8f0ceb9136ad43e1a08d0502b1d140ba
出典データセット
uspto-grants-1992_03
特許番号
US05100910

反応ノート

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