Dimethylformamide → 4-Chloro-7-nitroquinazoline

HRID 237316

反応式

HRID 237316 の反応式
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([C:8](=O)[NH:9][CH:10]=[N:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].CN(C=O)C.S(Cl)([Cl:22])=O>>[Cl:22][C:8]1[C:7]2[C:12](=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)[N:11]=[CH:10][N:9]=1

参加物

4

反応物 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 862228007-Nitroquinazolin-4(3H)-one

生成物 1

HCID 8306804-Chloro-7-nitroquinazoline

実験手順

To a solution of 7-nitroquinazolin-4(3H)-one (2.0 g, 10.5 mmol) in 40 ml thionyl chloride was added 0.8 ml of DMF and the mixture was heated at reflux overnight then evaporated to dryness to provide crude 4-chloro-7-nitroquinazoline.

後処理

  1. temperaturethe mixture was heated
  2. temperatureat reflux overnight
  3. customthen evaporated to dryness

出典と根拠

ORDレコード
ord-f0f7d6401cd4487e98e4fe40bbd46dba
出典データセット
uspto-grants-2014_02
特許番号
US08642582B2

関連ノート

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