Benzoyl Peroxide → Methyl 5-(bromomethyl)pyrazine-2-carboxylate

HRID 2373851

反応式

HRID 2373851 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([CH3:11])=[CH:7][N:6]=1)=[O:4].C1C(=O)N([Br:19])C(=O)C1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([CH2:11][Br:19])=[CH:7][N:6]=1)=[O:4]

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 4650652-Pyrazinecarboxylic acid, 5-methyl-, methyl ester

生成物 1

HCID 21973569Methyl 5-(bromomethyl)pyrazine-2-carboxylate収率 29.6%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

To a solution of 5-methyl-pyrazine-2-carboxylic acid methyl ester (2.0 g, 13.146 mmol) in CCl4 (25 mL0 was added NBS (2.57 g, 14.461 mmol) and benzoyl peroxide (0.318 g, 1.314 mmol) and the solution was heated at 70 C. for 1 h. Upon cooling to RT, the organic layer was washed with NaHCO3, water, dried (Na2SO4), and concentrated under reduced pressure to give 0.900 g 5-Bromomethyl-pyrazine-2-carboxylic acid methyl ester.

後処理

  1. temperaturethe solution was heated at 70 C
  2. washthe organic layer was washed with NaHCO3, water
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-943813d9e5094dcda8d8d0ea79ce405a
出典データセット
uspto-grants-2008_12
特許番号
US07459472B2

関連ノート

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