N-bromobutanimide → HCID 178448705、化合物
反応式
[CH2:1]([N:5]1[C:13]2[NH:12][CH:11]=[N:10][C:9]=2[C:8]2=[N:14][N:15]=[CH:16][N:7]2[C:6]1=[O:17])[CH:2]([CH3:4])[CH3:3].[Br:18]N1C(=O)CCC1=O>C1COCC1>[Br:18][C:11]1[NH:12][C:13]2[N:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[C:6](=[O:17])[N:7]3[CH:16]=[N:15][N:14]=[C:8]3[C:9]=2[N:10]=1参加物
4
実験手順
To a solution of 6-isobutyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-i]purin-5-one (9.4 mg, 40 mmol) in THF (5 ml) was added N-bromosuccinimide (8 mg, 44.7 mmol). The mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated, and the residue was purified by preparative LCMS (method A) to provide the desired product. LCMS calculated for C10H12BrN6O (M+H): 311.0; found 310.9, 313.0.
後処理
- concentrationThe reaction mixture was concentrated
- customthe residue was purified by preparative LCMS (method A)
出典と根拠
- ORDレコード
- ord-5c3cbfb1fbb24edcb60d120c097f8ccd
- 出典データセット
- uspto-grants-2008_12
- 特許番号
- US07462624B2
反応ノート
読み込み中…