Hydrazine hydrate (1:1) → 4-Ethoxy-2-(methylsulfanyl)aniline
反応式
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[C:6]([S:13][CH3:14])[CH:5]=1)[CH3:2].O.NN>CCO.[Pd]>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[C:6]([S:13][CH3:14])[CH:5]=1)[CH3:2]参加物
5
反応条件
- 温度
- 90 °C
実験手順
To a solution of 4-ethoxy-2-methylsulfanyl-1-nitro-benzene (1.0 g, 5.4 mmol) in absolute EtOH (25 mL) at rt was added 40 mg of Pd/C (Aldrich, 10 wt. % on active carbon), followed by slow addition of hydrazine hydrate (0.5 mL). The resulting reaction mixture was refluxed at 90° C. for 3 h. It then cooled to rt, filtered through Celite, and then concentrated in vacuo to afford 4-ethoxy-2-methylsulfanyl-phenyl amine as a pale yellow oil: MS (ESI) 184 (M+H)+.
後処理
- customThe resulting reaction mixture
- temperatureIt then cooled to rt
- filtrationfiltered through Celite
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-7e85869067d641b596256e27fb72e044
- 出典データセット
- uspto-grants-2008_12
- 特許番号
- US07465730B2
反応ノート
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