Sodium Hydroxide → 4-Chloro-6-iodo-7H-pyrrolo(2,3-d)pyrimidine

HRID 2375814ノート

反応式

HRID 2375814 の反応式
[Cl:1][C:2]1[C:3]2[CH:10]=[C:9]([I:11])[N:8](S(C3C=CC=CC=3)(=O)=O)[C:4]=2[N:5]=[CH:6][N:7]=1.[OH-].[Na+]>C1COCC1>[Cl:1][C:2]1[C:3]2[CH:10]=[C:9]([I:11])[NH:8][C:4]=2[N:5]=[CH:6][N:7]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 574158854-Chloro-6-iodo-7-phenylsulfonyl-7H-pyrrolo[2,3-D]pyrimidine

生成物 1

HCID 457897324-Chloro-6-iodo-7H-pyrrolo(2,3-d)pyrimidine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of 4-chloro-6-iodo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine (538 mg, 1.283 mmol) in THF (6.0 mL) was added 5 M sodium hydroxide methanolic solution (1.8 mL, 0.009 mmol). After 10 min the solvent was removed under reduced pressure, sat. ammonium chloride solution (5.0 mL) was added and the mixture evaporated to dryness. The resulting solid was triturated with water to afford 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine. 1H NMR (d6-DMSO, 400 MHz) 6.90(1H, s) and 8.55 (1H, s).

後処理

  1. customAfter 10 min the solvent was removed under reduced pressure, sat. ammonium chloride solution (5.0 mL)
  2. additionwas added
  3. customthe mixture evaporated to dryness
  4. customThe resulting solid was triturated with water

出典と根拠

ORDレコード
ord-5c4292f5fdf44d3bbda0ba002cbe80b5
出典データセット
uspto-grants-2008_12
特許番号
US07465726B2

反応ノート

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