Cyclohexylamine → N-cyclohexyl-2-phenylprop-2-enamide

HRID 2379692

反応式

HRID 2379692 の反応式
[C:1]([OH:11])(=O)[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[CH2:3].CN1CCOCC1.ClC(OCC(C)C)=O.[CH:27]1([NH2:33])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH:27]1([NH:33][C:1](=[O:11])[C:2]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)=[CH2:3])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1

参加物

5

反応物 4

HCID 7965CyclohexylamineHCID 79724-MethylmorpholineHCID 62365Isobutyl chloroformateHCID 68114Atropic acid

生成物 1

HCID 343735N-cyclohexyl-2-phenylprop-2-enamide収率 28.9%

実験手順

This compound was made from atropic acid (10.48 g, 70.8 mmol), N-methylmorpholine (7.8 ml, 70.9 mmol), iso-butyl chloroformate C9.2 ml, 70.9 mmol), and cyclohexylamine (8.1. ml, 70.7 mmol) using the procedure described in Example 3. The crude product was purified by recrystallisation from cyclohexane to give the product (4.69 g), as white crystals, m.p. 131-133°. (Found: C, 78.7; H, 8.8; N, 5.95. C15H19NO requires C, 78.6; H, 8.35; N, 6.1%.)

後処理

  1. customThe crude product was purified by recrystallisation from cyclohexane

出典と根拠

ORDレコード
ord-cf2b8c01a3e149428f533c86fdc1e0b3
出典データセット
uspto-grants-1994_11
特許番号
US05364849

関連ノート

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