Pyridine → 1-(2,4-Dichlorophenyl)-propan-2-one oxime
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10](=O)[CH3:11].Cl.[NH2:14][OH:15].N1C=CC=CC=1>CO>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10](=[N:14][OH:15])[CH3:11]参加物
5
実験手順
A solution of 1-(2,4-dichlorophenyl)-propan-2-one (3.46 g, 16.7 mmole) in methanol (40 ml) was treated with hydroxylamine hydrochloride (1.40 g, 20.6 mmol) followed by pyridine (1.7 ml, 20.6 mmol). The resulting mixture was stirred at ambient temperature over night for 16 hours. The reaction mixture was poured onto water (200 ml). The solid product was collected by filtration, washed with water and dried (40° C., 100 mbar). 3.63 g (100% of theory) of 1-(2,4-dichlorophenyl)-propan-2-one oxime was obtained in form of a white solid (m.p. 120-124° C.).
後処理
- additionThe reaction mixture was poured onto water (200 ml)
- filtrationThe solid product was collected by filtration
- washwashed with water
- customdried (40° C., 100 mbar)
出典と根拠
- ORDレコード
- ord-c439a8191fa3444a9c6465158443decf
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08258169B2
反応ノート
読み込み中…