Pyridine → 3-Propionylamino-pyrazine-2-carboxylic acid amide

HRID 238240

反応式

HRID 238240 の反応式
[NH2:1][C:2]1[C:3]([C:8]([OH:10])=O)=[N:4][CH:5]=[CH:6][N:7]=1.N1C=C[CH:14]=[CH:13][CH:12]=1.[NH3:17].[OH2:18]>CN(C1C=CN=CC=1)C.C(OC(=O)CC)(=O)CC>[C:12]([NH:1][C:2]1[C:3]([C:8]([NH2:17])=[O:10])=[N:4][CH:5]=[CH:6][N:7]=1)(=[O:18])[CH2:13][CH3:14]

参加物

6

反応物 3

HCID 1049PyridineHCID 726563-Amino-2-pyrazinecarboxylic acidHCID 12896473Azane;hydrate

生成物 1

HCID 599935133-Propionylamino-pyrazine-2-carboxylic acid amide収率 43%

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 31263Propionic anhydride溶媒

実験手順

A mixture of 3-amino-pyrazine-2-carboxylic acid (20.9 g, 0.15 mol), pyridine (29.6 g, 0.375 mol) and DMAP (1.83 g, 15 mmol) in propionic acid anhydride (100 mL) was stirred at room temperature overnight. The reaction mixture was poured into NH3.H2O (500 mL) partially at 0° C. After stirred for 30 min at 0° C., the precipitated solid was filtered, washed with water, dried in air to give 3-propionylamino-pyrazine-2-carboxylic acid amide as a beige solid (12.4 g, 43%), which was used directly in the next step.

後処理

  1. stirringAfter stirred for 30 min at 0° C.
  2. filtrationthe precipitated solid was filtered
  3. washwashed with water
  4. customdried in air

出典と根拠

ORDレコード
ord-e462de6e1306463e8024cdb00ecdc717
出典データセット
uspto-grants-2014_02
特許番号
US08642609B2

関連ノート

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