Water → ((S)-1-((S)-1-phenylethyl)pyrrolidin-3-yl)methanol

HRID 2382984ノート

反応式

HRID 2382984 の反応式
[H-].[H-].[H-].[H-].[Li+].[Al+3].O=[C:8]1[N:12]([C@H:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH3:14])[CH2:11][C@@H:10]([C:21](OC)=[O:22])[CH2:9]1.O.[OH-].[Na+]>C1COCC1>[C:15]1([C@@H:13]([N:12]2[CH2:8][CH2:9][C@H:10]([CH2:21][OH:22])[CH2:11]2)[CH3:14])[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

参加物

6

反応物 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 13772856HCID 13772856、化合物HCID 21226445Aluminium lithium hydride

生成物 1

HCID 11084986((S)-1-((S)-1-phenylethyl)pyrrolidin-3-yl)methanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
0 °C

実験手順

To a suspension of LAH (20 g, 0.526 mol) in dried THF (400 mL) was added dropwise a solution of (S)-methyl 5-oxo-1-((S)-1-phenylethyl)pyrrolidine-3-carboxylate (M4) (50 g, 0.202 mol) in dried THF (50 mL) at 0° C. The mixture was heated to reflux overnight. The reaction mixture was cooled to 0° C. and treated with water (20 mL) and aqueous NaOH (10%, 20 mL). The slurry formed was filtered off and washed with THF. The combined filtrate was evaporated to give compound ((S)-1-((S)-1-phenylethyl)pyrrolidin-3-yl)methanol (M5), which was used directly in the next step.

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux overnight
  3. customThe slurry formed
  4. filtrationwas filtered off
  5. washwashed with THF
  6. customThe combined filtrate was evaporated

出典と根拠

ORDレコード
ord-9ccd7b7f9e7645a1abf4a19b682b2320
出典データセット
uspto-grants-2012_09
特許番号
US08263605B2

反応ノート

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