Azobisisobutyronitrile → 2-Bromomethyl-4-nitro-1-pentafluoroethyl-benzene

HRID 238459ノート

反応式

HRID 238459 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[C:11]([F:17])([F:16])[C:12]([F:15])([F:14])[F:13].CC(N=NC(C#N)(C)C)(C#N)C.C1C(=O)N([Br:37])C(=O)C1>C(Cl)(Cl)(Cl)Cl.C(Cl)Cl>[Br:37][CH2:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[C:11]([F:16])([F:17])[C:12]([F:14])([F:15])[F:13]

参加物

6

反応物 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 105871021-Pentafluoroethyl-2-methyl-4-nitro-benzene

生成物 1

HCID 219593672-Bromomethyl-4-nitro-1-pentafluoroethyl-benzene

試薬・触媒・溶媒 2

HCID 5943Carbon Tetrachloride溶媒HCID 6344Dichloromethane溶媒

実験手順

2-Methyl-4-nitro-1-pentafluoroethyl-benzene (2.55 g) was dissolved in CCl4 (30 ml) and AIBN (164 mg) and NBS (1.96 g) were added. The reaction was heated to reflux and stirred for 24 h. The mix was diluted with CH2Cl2, washed with sat'd NaHCO2, dried over MgSO4 and concentrated to give the compound as an oil which was used without further purification.

後処理

  1. temperatureThe reaction was heated
  2. temperatureto reflux
  3. washwashed with sat'd NaHCO2
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-de09dcfcf01c43daa253618bd250f2a1
出典データセット
uspto-grants-2014_02
特許番号
US08642624B2

反応ノート

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