Thionyl Chloride → 2-Fluoropyridine-3-carbonyl chloride

HRID 238523

反応式

HRID 238523 の反応式
[F:1][C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][CH:5]=[CH:4][N:3]=1.O=S(Cl)[Cl:13]>>[F:1][C:2]1[C:7]([C:8]([Cl:13])=[O:10])=[CH:6][CH:5]=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 960892-Fluoronicotinic acid

生成物 1

HCID 219595822-Fluoropyridine-3-carbonyl chloride

実験手順

2-Fluoropyridine-3-carboxylic acid (7 g, Step C) was suspended in SOCl2 (100 mL). After heating under reflux for 2 h, the mixture became homogeneous. Excess SOCl2 was removed in vacuo to afford a brown solid as desired product.

後処理

  1. temperatureAfter heating
  2. temperatureunder reflux for 2 h
  3. customExcess SOCl2 was removed in vacuo

出典と根拠

ORDレコード
ord-9a43b48ccf53428fb07ec0624f068c33
出典データセット
uspto-grants-2014_02
特許番号
US08642624B2

関連ノート

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