Hydroxyamine hydrochloride → (E)-1-(6-bromo-pyridin-2-yl)-ethanone oxime
反応式
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Br:10])[N:5]=1)(=O)[CH3:2].Cl.[NH2:12][OH:13]>N1C=CC=CC=1>[Br:10][C:6]1[N:5]=[C:4](/[C:1](=[N:12]\[OH:13])/[CH3:2])[CH:9]=[CH:8][CH:7]=1参加物
4
実験手順
A mixture of 2-acetyl-6-bromopyridine (10.0 g, 0.050 mol) and hydroxylamine hydrochloride (6.90 g, 0.10 mol) in pyridine (50 mL) was stirred at room temperature overnight. The solvent was removed under reduced pressure, and the residue was diluted with ethyl acetate (200 mL), washed with water (100 mL), and dried over anhydrous sodium sulfate. Concentration under reduced pressure afforded a 10.75 g of A461.1 as an off-white solid.
後処理
- customThe solvent was removed under reduced pressure
- additionthe residue was diluted with ethyl acetate (200 mL)
- washwashed with water (100 mL)
- dry with materialdried over anhydrous sodium sulfate
- concentrationConcentration under reduced pressure
- customafforded a 10.75 g of A461.1 as an off-white solid
出典と根拠
- ORDレコード
- ord-a7f62be5e1b349559ce3355e664fec1d
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08268855B2
反応ノート
読み込み中…