p-Toluenesulfonic acid → HCID 68643976、化合物
反応式
[C:1]([N:4]1[CH2:9][CH2:8][C:7](=O)[CH2:6][CH:5]1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:3])[CH3:2].[NH:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1.CC1C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[C:11]1([CH:5]2[CH:6]=[C:7]([N:17]3[CH2:21][CH2:20][CH2:19][CH2:18]3)[CH2:8][CH2:9][N:4]2[C:1](=[O:3])[CH3:2])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1参加物
5
実験手順
To a mixture of 1-acetyl-2-phenylpiperidin-4-one (3.364 mmol, 1.0 eq.) and pyrrolidine (3.7 mmol, 1.1 eq.) in toluene (16 ml) was added PTSA (0.336 mmol, 0.1 eq.) and the reaction mixture was heated to reflux for 5 h using a Dean-Stark apparatus. After completion of the reaction, the solvent was evaporated under reduced pressure to obtain the crude product which was used in the next step without further purification.