Water → HCID 178447445、化合物

HRID 2389184ノート

反応式

HRID 2389184 の反応式
C[O:2][C:3](=[O:32])[CH2:4][CH2:5][C:6]([N+:29]([O-:31])=[O:30])([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:18][C@H:19]3[CH2:24][CH2:23][C@H:22]([C:25]([F:28])([F:27])[F:26])[CH2:21][CH2:20]3)[CH:14]=2)[CH:9]=1)[CH3:7].[OH-].[Li+].O>CO.O1CCCC1>[N+:29]([C:6]([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:18][C@H:19]3[CH2:20][CH2:21][C@H:22]([C:25]([F:26])([F:27])[F:28])[CH2:23][CH2:24]3)[CH:14]=2)[CH:9]=1)([CH3:7])[CH2:5][CH2:4][C:3]([OH:32])=[O:2])([O-:31])=[O:30]

参加物

6

反応物 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 178500165HCID 178500165、化合物

生成物 1

HCID 178447445HCID 178447445、化合物

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 4-nitro-4-[6-(trans-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-pentanoic acid methyl ester (0.098 g, 0.22 mmol) in methanol (1.00 mL, Fisher) and tetrahydrofuran (1.00 mL, Acros) was added 2 M lithium hydroxide in water (1.00 mL, 2.00 mmol). The mixture was stirred at room temperature. After 2 hours, the mixture was concentrated under vacuum. The resulting product was diluted in methylene chloride and washed with 1N HCl. The combined organic phases were dried over Na2SO4, filtered and concentrated to give the product in 99 mg yield (100%).

後処理

  1. concentrationthe mixture was concentrated under vacuum
  2. additionThe resulting product was diluted in methylene chloride
  3. washwashed with 1N HCl
  4. dry with materialThe combined organic phases were dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customto give the product in 99 mg
  8. customyield (100%)

出典と根拠

ORDレコード
ord-a35db02ee49c4cb18f50c7eda089f54d
出典データセット
uspto-grants-2012_09
特許番号
US08269043B2

反応ノート

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