Hydrochloric Acid → 2-Furanacrylic acid

HRID 2389863

反応式

HRID 2389863 の反応式
[CH:1]1[CH:5]=[C:4]([CH:6]=O)[O:3][CH:2]=1.C(O)(=O)[CH2:9][C:10]([OH:12])=[O:11].N1CCCCC1.Cl>N1C=CC=CC=1.O>[O:3]1[CH:2]=[CH:1][CH:5]=[C:4]1/[CH:6]=[CH:9]/[C:10]([OH:12])=[O:11]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 7362FurfuralHCID 8082Piperidine

生成物 1

HCID 6434022-Furanacrylic acid収率 92%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1049Pyridine溶媒

反応条件

温度
100 °C

実験手順

To a mixture of 2-furfural (500 g, 5.20 mol) and malonic acid (595 g, 5.72 mol) in pyridine (500 mL) was added piperidine (50 mL, 0.505 mol) at room temperature, and the mixture was stirred at 100° C. for 3 hr. The reaction solution was poured into water (1 L) and acidified with 6M hydrochloric acid. The resulting precipitate was collected by filtration to give the title compound (660 g, yield 92%).

後処理

  1. filtrationThe resulting precipitate was collected by filtration

出典と根拠

ORDレコード
ord-f4f5782bb6ab4fe5b912f3315f5b6e9d
出典データセット
uspto-grants-2012_09
特許番号
US08273761B2

関連ノート

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