Nitric Acid → 5-nitro-2H,3H-furo(3,2-b)pyridine
反応式
[O:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[N+:10]([O-])([OH:12])=[O:11].[OH-].[Na+]>S(=O)(=O)(O)O.O>[N+:10]([C:6]1[N:5]=[C:4]2[CH2:3][CH2:2][O:1][C:9]2=[CH:8][CH:7]=1)([O-:12])=[O:11]参加物
6
実験手順
To a solution of 2,3-dihydrofuro[3,2-b]pyridine (32.9 g, 271 mmol) in sulfuric acid (50 mL) was added dropwise a mixed solution of fuming nitric acid (20 mL) and sulfuric acid (20 mL) under ice-cooling, and the mixture was stirred at room temperature for 1 hr. The reaction solution was neutralized with 8M aqueous sodium hydroxide solution and diluted with water. The resulting crystals were collected by filtration to give the title compound (37.5 g, yield 83%).
後処理
- temperaturecooling
- filtrationThe resulting crystals were collected by filtration
出典と根拠
- ORDレコード
- ord-5621e300975e47449c669a90da97605b
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273761B2
反応ノート
読み込み中…