Trifluoroacetic acid → N-(5,6,7,8-Tetrahydro-4H-thiazolo[4,5-d]azepin-2-yl)-acetamide
反応式
FC(F)(F)C(O)=O.C(OC([N:15]1[CH2:21][CH2:20][C:19]2[S:22][C:23]([NH:25][C:26](=[O:28])[CH3:27])=[N:24][C:18]=2[CH2:17][CH2:16]1)=O)(C)(C)C>C(Cl)(Cl)Cl>[S:22]1[C:19]2[CH2:20][CH2:21][NH:15][CH2:16][CH2:17][C:18]=2[N:24]=[C:23]1[NH:25][C:26](=[O:28])[CH3:27]参加物
4
実験手順
35 mL trifluoroacetic acid was added to 2.4 g 2-acetylamino-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepine-6-carboxylic acid tert-butyl ester in 80 mL chloroform. The reaction was stirred 3 h at RT and concentrated. The residue was dissolved in 75 mL chloroform and basified with 2.5 M potassiumcarbonate solution. The chloroform layer was separated and concentrated to give 1.3 g of the desired product. (M+H)+=212
後処理
- concentrationconcentrated
- dissolutionThe residue was dissolved in 75 mL chloroform and basified with 2.5 M potassiumcarbonate solution
- customThe chloroform layer was separated
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-c1f2abfcfb954a499351fdb7eca5dc44
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642774B2
反応ノート
読み込み中…