反応式
[CH2:1]([O:8][C:9]([N:11]1[CH2:17][CH2:16][C:15](=O)[CH:14]([NH:19][C:20](=[O:22])[CH3:21])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].COC(NS([N+](CC)(CC)CC)(=O)=O)=O>O1CCCC1>[CH3:21][C:20]1[O:22][C:15]2[CH2:16][CH2:17][N:11]([C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[O:10])[CH2:12][CH2:13][C:14]=2[N:19]=1参加物
4
実験手順
3 g 4-acetylamino-5-oxo-azepane-1-carboxylic acid benzyl ester in 100 mL tetrahydrofuran and 3.8 g (methoxycarbonylsulfamoyl)triethylammonium hydroxide were heated in a sealed tube at 75° C. for 1 h. The solvent was evaporated and the residue was purified by chromatographie on silica gel (ethyl acetate/hexane 1:2) to yield 23 g of the desired product. (M+H)+: 287
後処理
- customThe solvent was evaporated
- customthe residue was purified by chromatographie on silica gel (ethyl acetate/hexane 1:2)
出典と根拠
- ORDレコード
- ord-70918a54ec1b45ceb69878ad78586d14
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642774B2
関連ノート
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