3-Fluoro-4-methylaniline → 3-Fluoro-4-methylphenyl methyl sulfide

HRID 2393039

反応式

HRID 2393039 の反応式
N(OC(C)(C)C)=O.[F:8][C:9]1[CH:10]=[C:11]([CH:13]=[CH:14][C:15]=1[CH3:16])N.[CH3:17][S:18]SC>C(Cl)(Cl)Cl>[F:8][C:9]1[CH:10]=[C:11]([S:18][CH3:17])[CH:13]=[CH:14][C:15]=1[CH3:16]

参加物

5

反応物 3

HCID 99573-Fluoro-4-methylaniline2 回HCID 10906Tert-Butyl nitrite2 回HCID 12232Dimethyl Disulfide

生成物 1

HCID 534144923-Fluoro-4-methylphenyl methyl sulfide

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

t-Butyl nitrite (4 ml) was added to a mixture of 3-fluoro-4-methylaniline (5 g) and dimethyldisulphide (36 ml) in chloroform. After the reaction had initiated t-butyl nitrite (22 ml) and a solution of 3-fluoro-4-methylaniline (20.0 g) in chloroform were added simultaneously. The mixture was then stirred at room temperature for 2 hours. The mixture was washed with water, hydrochloric acid (2M), water, dried (MgSO4) and filtered. The filtrate was evaporated to dryness to give 2-fluoro-4-(methylsulphenyl)toluene (25.37 g) as a red oil which was not further purified.

後処理

  1. washThe mixture was washed with water, hydrochloric acid (2M), water
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. customThe filtrate was evaporated to dryness

出典と根拠

ORDレコード
ord-71c25232191642829750fad44fcb71ff
出典データセット
uspto-grants-1998_09
特許番号
US05804532

関連ノート

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