Chloroform → 2-(1-Hydroxyiminoethyl)-4-[4-(2-hydroxyethyl)piperazin-1-ylmethyl]phenol

HRID 23936ノート

反応式

HRID 23936 の反応式
Cl.[NH2:2][OH:3].C(=O)(O)[O-].[Na+].[C:9]([C:12]1[CH:17]=[C:16]([CH2:18][N:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][OH:27])[CH2:21][CH2:20]2)[CH:15]=[CH:14][C:13]=1[OH:28])(=O)[CH3:10].C(Cl)(Cl)Cl>O.CO>[OH:3][N:2]=[C:9]([C:12]1[CH:17]=[C:16]([CH2:18][N:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][OH:27])[CH2:21][CH2:20]2)[CH:15]=[CH:14][C:13]=1[OH:28])[CH3:10]

参加物

7

反応物 4

HCID 6212ChloroformHCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 98604522-Acetyl-4-[4-(2-hydroxyethyl)piperazin-1-yl-methyl]phenol

生成物 1

HCID 1359919502-(1-Hydroxyiminoethyl)-4-[4-(2-hydroxyethyl)piperazin-1-ylmethyl]phenol収率 81%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
65 °C

実験手順

Hydroxylamine hydrochloride (63 mg, 0.9 mmol) and sodium bicarbonate (76 mg, 0.9 mmol) were dissolved in distilled water (1 ml). 2-Acetyl-4-[4-(2-hydroxyethyl)-piperazin-1-yl-methyl]phenol (85 mg, 0.3 mmol) in absolute methanol (2 ml) was added and the reaction mixture was stirred at 65° C. for 24 h. CHCl3 (20 ml) was then added, the organic phase washed with water followed by brine, dried over Na2SO4, filtered and evaporated to obtain the title product (52 mg, 81%).

後処理

  1. washthe organic phase washed with water
  2. dry with materialdried over Na2SO4
  3. filtrationfiltered
  4. customevaporated

出典と根拠

ORDレコード
ord-16df7836f55644e0b2139ea2dbbfac49
出典データセット
uspto-grants-2005_02
特許番号
US06855711B1

反応ノート

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