Ethyl Bromide → 2-(3-Ethoxyphenyl)-4,5-dihydropyrazolo[1,5-a]quinoline

HRID 2398082ノート

反応式

HRID 2398082 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:20]=[C:11]3[CH2:12][CH2:13][C:14]4[C:19]([N:10]3[N:9]=2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:5]=[CH:6][CH:7]=1.[Na].[CH2:22](Br)[CH3:23]>C(O)C>[CH2:22]([O:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:20]=[C:11]3[CH2:12][CH2:13][C:14]4[C:19]([N:10]3[N:9]=2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:5]=[CH:6][CH:7]=1)[CH3:23]

参加物

5

反応物 3

HCID 6332Ethyl BromideHCID 3042689Phenol, 3-(4,5-dihydropyrazolo(1,5-a)quinolin-2-yl)-HCID 5360545Sodium

生成物 1

HCID 134125132-(3-Ethoxyphenyl)-4,5-dihydropyrazolo[1,5-a]quinoline

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2.62 Grams (0.010 mole) of the compound of Example 10 is added to a solution of 0.23 g. (0.010 mole) of sodium in 40 ml. of absolute ethanol at room temperature, then 2.2 g. (0.020 mole) of ethyl bromide is added dropwise. The resulting solution is refluxed for seven hours and allowed to stand overnight at room temperature. After dilution with 30 ml. of water and subsequent evaporation of the ethanol, a residue is obtained which is crystallized from methanol. Yield 2.29 g. of the title compound, m.p. 99°-100° C.

後処理

  1. customat room temperature
  2. temperatureThe resulting solution is refluxed for seven hours
  3. customof water and subsequent evaporation of the ethanol
  4. customa residue is obtained which
  5. customis crystallized from methanol

出典と根拠

ORDレコード
ord-5ee4a91051b24501ab41c0447622520e
出典データセット
uspto-grants-1977_05
特許番号
US04024149

反応ノート

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