反応式
[CH3:1][S:2]([CH2:5][C:6]#N)(=[O:4])=[O:3].[CH3:8]I.[H-].[Na+].O.C[N:14]([CH3:17])C=O>>[CH3:8][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])([CH3:6])[C:17]#[N:14]参加物
6
実験手順
To a solution of methylsulfonylacetonitrile (25 g) and methyl iodide (27.4 mL) in N,N-dimethylformamide (300 mL) was added sodium hydride (20 g) at 0° C., and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (18 g, yield 58%) as colorless crystals.
後処理
- extractionthe mixture was extracted with ethyl acetate
- washThe organic layer was washed with saturated brine
- dry with materialdried over anhydrous magnesium sulfate
- customthe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-e00a7859e5e942a5988e009082c9e4a9
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642770B2
関連ノート
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