Sodium Hydroxide → (3,4-Bis(difluoromethoxy)phenyl)methanol

HRID 2399401ノート

反応式

HRID 2399401 の反応式
[F:1][CH:2]([F:16])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH:13]([F:15])[F:14])[CH:7]=[O:8].[BH4-].[Na+].[OH-].[Na+]>C(O)C>[F:1][CH:2]([F:16])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH:13]([F:15])[F:14])[CH2:7][OH:8]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 4311764Sodium borohydrideHCID 145092693,4-Bis(difluoromethoxy)benzaldehyde

生成物 1

HCID 53484633(3,4-Bis(difluoromethoxy)phenyl)methanol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

3,4-Bisdifluoromethoxybenzaldehyde (26.2 g, 110 mmol) in absolute ethanol (150 mL) was treated with sodium borohydride (8.32 g, 220 mmol) under an argon atmosphere at room temperature for 0.5 h. Ten percent aqueous sodium hydroxide (130 mL) was added, the ethanol was removed in vacuo, the mixture was partitioned between ether and water and was extracted twice with ether. The organic extract was dried (magnesium sulfate) and evaporated to a pale yellow oil (26.4 g, 100%).

後処理

  1. customthe ethanol was removed in vacuo
  2. customthe mixture was partitioned between ether and water
  3. extractionwas extracted twice with ether
  4. extractionThe organic extract
  5. dry with materialwas dried (magnesium sulfate)
  6. customevaporated to a pale yellow oil (26.4 g, 100%)

出典と根拠

ORDレコード
ord-9de5e2df346e4c9c9cecf86fa802887b
出典データセット
uspto-grants-1995_09
特許番号
US05449686

反応ノート

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