反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](NCC(O)=O)=[CH:4][CH:3]=1.CN(C)C=[O:16].P(Cl)(Cl)Cl.[F:22][C:23]([F:28])([F:27])[C:24](Cl)=[O:25].[C:29](#[N:31])[CH3:30]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:29]2[C:30](=[O:16])[O:25][CH:24]([C:23]([F:28])([F:27])[F:22])[N:31]=2)=[CH:6][CH:7]=1参加物
6
実験手順
A solution of p-chlorophenylglycine (46.9 g, 0.25 mole) in a mixture of acetonitrile, xylenes and dimethyl formamide (74.8 w/w%, 24.9 w/w% and 0.3 w/w%, respectively) is treated sequentially with PCl3 (21.3 g, 0.155 mole) and trifluoroacetyl chloride (34.8 g, 0.26 mole), held at 40° C. for 0.5 hour, heated at 60° -65° C. for 8 hours and allowed to cool to room temperature. The title product is obtained in quantitative yield by HPLC analysis.
後処理
- temperatureheated at 60° -65° C. for 8 hours
出典と根拠
- ORDレコード
- ord-6e69ef7220c84e688f426d9d2773d60b
- 出典データセット
- uspto-grants-1995_09
- 特許番号
- US05453508
関連ノート
読み込み中…