N-bromobutanimide → 5-Bromo-6-chloro-2-methanesulfinylpyrimidin-4-amine

HRID 2401160

反応式

HRID 2401160 の反応式
[Br:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[N:15]=[C:14]([S:16]([CH3:18])=[O:17])[N:13]=[C:12]([NH2:19])[CH:11]=1>CN(C=O)C>[Br:1][C:11]1[C:12]([NH2:19])=[N:13][C:14]([S:16]([CH3:18])=[O:17])=[N:15][C:10]=1[Cl:9]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 15563630HCID 15563630、化合物

生成物 1

HCID 866770165-Bromo-6-chloro-2-methanesulfinylpyrimidin-4-amine収率 81%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

11.2 g (62.6 mmol) de N-bromosuccinimide were slowly added to a cooled suspension of 10 g (52.2 mmol) 6-chloro-2-(methylsulfinyl)pyrimidine-4-amine in 130 ml of DMF. After 50 minutes stirring at room temperature the precipitate was filtered washed with cool DMF, several times with cool water and dried in vacuum. There was obtained 11.4 g (81%) of a white solid.

後処理

  1. filtrationwas filtered
  2. washwashed with cool DMF, several times with cool water
  3. customdried in vacuum

出典と根拠

ORDレコード
ord-ab2294b0b0e240c9a93440f63ec30081
出典データセット
uspto-grants-2014_08
特許番号
US08796284B2

関連ノート

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