7-(Benzyloxy)-[1,2,4]triazolo[1,5-a]pyridine → HCID 178516352、化合物

HRID 240584ノート

反応式

HRID 240584 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][N:12]2[N:15]=[CH:16][N:17]=[C:11]2[CH:10]=1)C1C=CC=CC=1>[Pd].C1COCC1>[N:17]1[CH:16]=[N:15][N:12]2[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][C:11]=12

参加物

4

反応物 1

HCID 669371067-(Benzyloxy)-[1,2,4]triazolo[1,5-a]pyridine

生成物 1

HCID 178516352HCID 178516352、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A 250 mL, single-neck, round-bottomed flask was charged with 7-(benzyloxy)-[1,2,4]triazolo[1,5-a]pyridine (3.20 g, 14.2 mmol), Pd/C (0.756 g, 0.710 mmol), and THF (125 mL). The reaction was stirred under an atmosphere of hydrogen for 16 hours, then filtered (GF paper) and concentrated to a white solid. The solids were titrated with EtOAc and collected by filtration to provide the desired product.

後処理

  1. filtrationfiltered (GF paper)
  2. concentrationconcentrated to a white solid
  3. filtrationcollected by filtration

出典と根拠

ORDレコード
ord-8dc86bf5530f48a88256ee9f41785e31
出典データセット
uspto-grants-2014_02
特許番号
US08648087B2

反応ノート

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