Ammonium formate → (S)-1-(3-(2-amino-5-methylphenoxy)piperidin-1-yl)-2,2,2-trifluoroethanone

HRID 240601ノート

反応式

HRID 240601 の反応式
C([O-])=O.[NH4+].[F:5][C:6]([F:27])([F:26])[C:7]([N:9]1[CH2:14][CH2:13][CH2:12][C@H:11]([O:15][C:16]2[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=2[N+:23]([O-])=O)[CH2:10]1)=[O:8]>[Pd].CO>[NH2:23][C:17]1[CH:18]=[CH:19][C:20]([CH3:22])=[CH:21][C:16]=1[O:15][C@H:11]1[CH2:12][CH2:13][CH2:14][N:9]([C:7](=[O:8])[C:6]([F:27])([F:5])[F:26])[CH2:10]1

参加物

5

反応物 2

HCID 2723923Ammonium formateHCID 58413139(S)-2,2,2-trifluoro-1-(3-(5-methyl-2-nitrophenoxy)piperidin-1-yl)ethanone

生成物 1

HCID 58413119(S)-1-(3-(2-amino-5-methylphenoxy)piperidin-1-yl)-2,2,2-trifluoroethanone

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Amoniumformiate (0.238 g) was added into a suspension of (S)-2,2,2-trifluoro-1-(3-(5-methyl-2-nitrophenoxy)piperidin-1-yl)ethanone and palladium on charcoal (50.0 mg) in MeOH (6.0 ml) at room temperature. The mixture was heated at reflux for 40 mins. The mixture was filtered through a pad of celite and the filtercake was washed with dichloromethane. The filtrate was washed with water and. The residue was purfied by chromatography.

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 40 mins
  3. filtrationThe mixture was filtered through a pad of celite
  4. washthe filtercake was washed with dichloromethane
  5. washThe filtrate was washed with water

出典と根拠

ORDレコード
ord-300843a7813441c6b1ca2abcb34f42f2
出典データセット
uspto-grants-2014_02
特許番号
US08648068B2

反応ノート

読み込み中…