Acetic Anhydride → 2-Methylpropyl 5-bromo-4-fluoro-2-methyl-1H-benzimidazole-1-carboxylate

HRID 241029ノート

反応式

HRID 241029 の反応式
[Br:1][C:2]1[C:3]([F:10])=[C:4]([NH2:9])[C:5]([NH2:8])=[CH:6][CH:7]=1.[C:11](OC(=O)C)(=O)[CH3:12].Cl[C:19]([O:21][CH2:22][CH:23]([CH3:25])[CH3:24])=[O:20]>O1CCCC1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[N:8]([C:19]([O:21][CH2:22][CH:23]([CH3:25])[CH3:24])=[O:20])[C:11]([CH3:12])=[N:9][C:4]=2[C:3]=1[F:10]

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 62365Isobutyl chloroformateHCID 27832034-Bromo-3-fluorobenzene-1,2-diamine

生成物 1

HCID 687771362-Methylpropyl 5-bromo-4-fluoro-2-methyl-1H-benzimidazole-1-carboxylate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Synthesized according to the method of reagent preparation 19 using 5 4-bromo-3-fluorobenzene-1,2-diamine and acetylation with acetic anhydride in tetrahydrofurane in step 1 then treatment with isobutyl chloroformate in step 3. MS (EI) for C13H14BrN2O2: 328, 330 (MH+, Br isotope pattern).

後処理

  1. customSynthesized

出典と根拠

ORDレコード
ord-021d83c5fbf44ad4bd64e1e375e77f4e
出典データセット
uspto-grants-2014_02
特許番号
US08648066B2

反応ノート

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