Perchloric Acid → 3-{2-[(2R,3R,4S,5R)-4,5-dihydroxy-2-{2-[4-(6-methoxypyridin-3-yl)phenyl]ethyl}tetrahydrofuran-3-yl]ethyl}-1,2,3-benzotriazin-4(3H)-one

温度

55 °C

Perchloric acid (4.8 mL) was added to a solution of the compound obtained from step c above (8.1 g) in acetonitrile (50 mL) and water (8 mL) at room temperature. The reaction mixture was heated to 55° C. for 30 minutes. The reaction mixture was then quenched using sodium bicarbonate solution. The solvents were evaporated under reduced pressure. The residue thus obtained was taken up in ethyl acetate and water. The organic layer was separated, washed with water and brine solution, and dried over anhydrous sodium sulphate. The solvent was concentrated under reduced pressure to yield the title compound (8 g).

1. customat room temperature
2. customThe reaction mixture was then quenched
3. customThe solvents were evaporated under reduced pressure
4. customThe residue thus obtained
5. customThe organic layer was separated
6. washwashed with water and brine solution
7. dry with materialdried over anhydrous sodium sulphate
8. concentrationThe solvent was concentrated under reduced pressure

ORDレコード

ord-046f68b5eb914bdcbd18229c65fe6709

出典データセット

uspto-grants-2014_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08816073B2