O-Methylhydroxylamine → N-(5-tert-Butyl-1,2-oxazol-3-yl)-N'-methoxyurea

HRID 2412533ノート

反応式

HRID 2412533 の反応式
[CH3:1][O:2][NH2:3].[N:4]([C:7]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[O:9][N:8]=1)=[C:5]=[O:6]>O1CCCC1>[CH3:1][O:2][NH:3][C:5]([NH:4][C:7]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[O:9][N:8]=1)=[O:6]

参加物

4

反応物 2

HCID 4113O-MethylhydroxylamineHCID 129188385-Tert-butyl-3-isocyanato-1,2-oxazole

生成物 1

HCID 13370466N-(5-tert-Butyl-1,2-oxazol-3-yl)-N'-methoxyurea

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

8.5 g of methoxyamine was added very slowly to a stirred solution of 15 g of 4A in 600 ml of tetrahydrofuran. The resulting mixture was filtered and the solid was triturated with ether to give 1-methoxy-3-(5-(tertiary-butyl)-1,2-oxazol-3-yl)urea (4B), m.p.: 145°-148° C.

後処理

  1. filtrationThe resulting mixture was filtered
  2. customthe solid was triturated with ether

出典と根拠

ORDレコード
ord-913f2808d8284d4d91ad6f7602ea6369
出典データセット
uspto-grants-1985_01
特許番号
US04493728

反応ノート

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