Formaldehyde → 7-Bromo-2-dimethylaminomethyl-1-tetralone hydrochloride

HRID 2413264ノート

反応式

HRID 2413264 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][C:9]2=[O:12])=[CH:4][CH:3]=1.[ClH:13].[CH3:14][NH:15][CH3:16].[CH2:17]=O>Cl.C(O)C>[ClH:13].[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH:8]([CH2:14][N:15]([CH3:17])[CH3:16])[C:9]2=[O:12])=[CH:4][CH:3]=1

参加物

6

反応物 3

HCID 712FormaldehydeHCID 10473Dimethylamine, hydrochlorideHCID 2527317-Bromo-1,2,3,4-tetrahydronaphthalen-1-one

生成物 1

HCID 233209337-Bromo-2-dimethylaminomethyl-1-tetralone hydrochloride

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid触媒HCID 702Ethanol溶媒

実験手順

A mixture of 7-bromo-1-tetralone (4.50 g), dimethylamine hydrochloride (2.50 g), paraformaldehyde (1.0 g), ethanol (6 ml) and concentrated hydrochloric acid (4 drops) was heated under reflux for two hours and cooled. The mixture was diluted with a few ml. of acetone and the solid was filtered off, washed with a little acetone and dried to give 7-bromo-2-dimethylaminomethyl-1-tetralone hydrochloride, m.p. 169°-171°, pure enough for further reaction.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for two hours
  3. temperaturecooled
  4. additionThe mixture was diluted with a few ml
  5. filtrationof acetone and the solid was filtered off
  6. washwashed with a little acetone
  7. customdried

出典と根拠

ORDレコード
ord-51f045b541964c298852d3873cb3fc6d
出典データセット
uspto-grants-1985_01
特許番号
US04496572

反応ノート

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