Adenine → HCID 13536441、化合物

HRID 2413514ノート

反応式

HRID 2413514 の反応式
[S:1]1[CH:5]=[CH:4][C:3]([C:6](Cl)=[O:7])=[CH:2]1.[N:9]1[C:17]([NH2:18])=[C:16]2[C:12]([N:13]=[CH:14][NH:15]2)=[N:11][CH:10]=1>N1C=CC=CC=1>[CH:2]1[S:1][CH:5]=[CH:4][C:3]=1[C:6]([NH:18][C:17]1[N:9]=[CH:10][N:11]=[C:12]2[C:16]=1[NH:15][CH:14]=[N:13]2)=[O:7]

参加物

4

反応物 2

HCID 190AdenineHCID 27763773-Thenoyl chloride

生成物 1

HCID 13536441HCID 13536441、化合物収率 60%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

62.6 g (0.439 mole) of thiophene-3-carbonyl chloride are added to a suspension of 19.7 g (0.146 mole) of adenine in 100 ml of dry pyridine. The mixture is refluxed for 10 hours, the pyridine is distilled off, the residue is taken up in chloroform, the solution is washed with dilute sodium bicarbonate solution and dried over sodium sulfate, and the solvent is then stripped off in a rotary evaporator. The solid residue is stirred repeatedly with cyclohexane and then recrystallized from ethanol and dried at about 40° C. under reduced pressure. 6-(3-Thenoylamino)-purine is obtained in a yield of 60%.

後処理

  1. temperatureThe mixture is refluxed for 10 hours
  2. distillationthe pyridine is distilled off
  3. washthe solution is washed with dilute sodium bicarbonate solution
  4. dry with materialdried over sodium sulfate
  5. customthe solvent is then stripped off in a rotary evaporator
  6. customrecrystallized from ethanol
  7. customdried at about 40° C. under reduced pressure

出典と根拠

ORDレコード
ord-aec47a022e1740a7b713de7f63dd8bc5
出典データセット
uspto-grants-1988_01
特許番号
US04718936

反応ノート

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