2,3-Diaminopyridine → HCID 66869810、化合物

HRID 241412

反応式

HRID 241412 の反応式
[NH2:1][C:2]1[N:10]=[CH:9][C:8]([Br:11])=[CH:7][C:3]=1[C:4](O)=O.[N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([NH2:18])[C:13]=1[NH2:19].[OH-].[Na+]>O>[Br:11][C:8]1[CH:7]=[C:3]([C:4]2[NH:18][C:14]3[C:13]([N:19]=2)=[N:12][CH:17]=[CH:16][CH:15]=3)[C:2]([NH2:1])=[N:10][CH:9]=1

参加物

5

反応物 3

HCID 99562,3-DiaminopyridineHCID 14798Sodium HydroxideHCID 7374452-Amino-5-bromonicotinic acid

生成物 1

HCID 66869810HCID 66869810、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
160 °C

実験手順

50 mg (0.230 mmol) I) of 2-amino-5-bromonicotinic acid and 27.6 mg (0.253 mmol) of pyridine-2,3-diamine are added to 451.5 mg (5 mmol) of polyphosphoric acid, and the mixture is stirred at 160° C. for 4 days. The reaction mixture is cooled to room temperature, water is added, and the mixture is adjusted to pH 12 by means of 1N NaOH. The precipitate formed is filtered off with suction and dried, giving 5-bromo-3-(1H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-ylamine.

後処理

  1. temperatureThe reaction mixture is cooled to room temperature
  2. customThe precipitate formed
  3. filtrationis filtered off with suction
  4. customdried

出典と根拠

ORDレコード
ord-725e8d02c86f429892222bd9e70741e6
出典データセット
uspto-grants-2014_02
特許番号
US08648201B2

関連ノート

読み込み中…