Phenol → 2-Chloro-6-phenoxypyridine

HRID 2415171

反応式

HRID 2415171 の反応式
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[C:9]1([OH:15])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[OH-].[Na+]>O>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([O:15][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1

参加物

5

反応物 3

HCID 996PhenolHCID 14798Sodium Hydroxide2 回HCID 169892,6-Dichloropyridine

生成物 1

HCID 8176622-Chloro-6-phenoxypyridine

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
140 °C

実験手順

A reaction mixture consisting of 1.48 g (10 mmol) of 2,6-dichloropyridine, 6 g (63.75 mmol) of phenol and 2.4 g (60 mmol) of sodium hydroxide in 10 ml of water is heated to 140° C. for 24 hours in a bomb. After cooling the reaction mixture is made strongly alkaline with sodium hydroxide solution and extracted with dichloromethane. The organic phase is separated off and dried over sodium sulphate. Purification is by column chromatography on silica gel (eluant: cyclohexane/ethyl acetate=3:1).

後処理

  1. temperatureAfter cooling the reaction mixture
  2. extractionextracted with dichloromethane
  3. customThe organic phase is separated off
  4. dry with materialdried over sodium sulphate
  5. customPurification

出典と根拠

ORDレコード
ord-ac707bb3264f428cb065a83624731042
出典データセット
uspto-grants-2004_11
特許番号
US06818644B1

関連ノート

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