Potassium Cyanide → 5-(4-Cyanobutyl)-imidazo[1,5-a]pyridine
反応式
Cl[CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[N:11]2[CH:12]=[N:13][CH:14]=[C:10]2[CH:9]=[CH:8][CH:7]=1.[C-:15]#[N:16].[K+].C1OCCOC2C(=CC=CC=2)OCCOCCOC2C(=CC=CC=2)OC1>C(#N)C>[C:15]([CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[N:11]2[CH:12]=[N:13][CH:14]=[C:10]2[CH:9]=[CH:8][CH:7]=1)#[N:16]参加物
5
実験手順
A solution of 5-(4-chlorobutyl)imidazo[1,5-a]pyridine (5.73 g), potassium cyanide (7.18 g) and 1.0 g of dibenzo-18-crown-6 in 190 ml of acetonitrile is heated at reflux for 18 hours, cooled and evaporated to a residual oil which is partitioned between water and methylene chloride. The organic phase is dried over sodium sulfate and evaporated. The resulting solid is dissolved in ethyl acetate and filtered through 60.0 g of silica gel to yield 5-(4-cyanobutyl)-imidazo[1,5-a]pyridine m.p. 72°-75°.