1,2-Dihydro-6-fluoro-5-hydroxymethylquinaldine → 6-Fluoro-5-hydroxymethyl-1,2,3,4-tetrahydroquinaldine
反応式
[F:1][C:2]1[C:3]([CH2:13][OH:14])=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]([CH3:12])[CH:6]=[CH:5]2>C(O)C.Cl.[Pd].[Pt]>[F:1][C:2]1[C:3]([CH2:13][OH:14])=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]([CH3:12])[CH2:6][CH2:5]2参加物
6
実験手順
A solid which was chiefly 1,2-dihydro-6-fluoro-5-hydroxymethylquinaldine (7.0 g) was dissolved in 200 ml of ethanol containing 1 ml of concentrated hydrochloric acid, 1.0 g of 5% palladium on charcoal, and 1.0 g 5% platinum on charcoal and the mixture was hydrogenated at 50 psi at 20° C. for 5 hours. The solution was filtered and the filtrate was evaporated to provide white solid 6-fluoro-5-hydroxymethyl-1,2,3,4-tetrahydroquinaldine as determined by nuclear magnetic resonance spectral analysis.
後処理
- filtrationThe solution was filtered
- customthe filtrate was evaporated
出典と根拠
- ORDレコード
- ord-ab5319c31ff2467e9fd4335e71cfea98
- 出典データセット
- uspto-grants-1984_09
- 特許番号
- US04472405
反応ノート
読み込み中…