Pyrrolidine → HCID 54067199、化合物
反応式
[CH2:1]([C:6](=[CH:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:11]=1[Cl:17])[CH2:7]Br)[CH2:2][CH2:3][CH2:4][CH3:5].[NH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1>C(Cl)(Cl)Cl>[CH2:1]([C:6](=[CH:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:11]=1[Cl:17])[CH2:7][N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)[CH2:2][CH2:3][CH2:4][CH3:5]参加物
4
反応条件
- 温度
- 150 °C
実験手順
A mixture of 50 g of (III) and 31.7 g of pyrrolidine was heated for 5 hours at 150° C. in an oil bath. The crude product was cooled, and dissolved in CHCl3, and the solution was washed with dilute NaOH and then several times with water. The organic phase was dried over Na2SO4 and concentrated. Distillation of the residue gave 19 g of (IV) of boiling point 148°-150° C./0.1 mbar.