Hydrochloric Acid → 2-Sulfamoyl-1,3-benzothiazol-6-yl dimethylcarbamate

HRID 2418290ノート

反応式

HRID 2418290 の反応式
[OH:1][C:2]1[CH:14]=[CH:13][C:5]2[N:6]=[C:7]([S:9]([NH2:12])(=[O:11])=[O:10])[S:8][C:4]=2[CH:3]=1.[CH3:15][N:16]([CH3:20])[C:17](Cl)=[O:18].Cl>CN(C)C1C=CN=CC=1.N1C=CC=CC=1>[CH3:15][N:16]([CH3:20])[C:17](=[O:18])[O:1][C:2]1[CH:14]=[CH:13][C:5]2[N:6]=[C:7]([S:9](=[O:11])(=[O:10])[NH2:12])[S:8][C:4]=2[CH:3]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 6598Dimethylcarbamoyl Chloride2 回HCID 68521296-Hydroxy-1,3-benzothiazole-2-sulfonamide

生成物 1

HCID 444619572-Sulfamoyl-1,3-benzothiazol-6-yl dimethylcarbamate収率 76,325.203%

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 1049Pyridine溶媒

実験手順

To a stirred solution of 6-hydroxy-2-benzothiazolesulfonamide (2.3 g, 0.01 mole) and 4-dimethylaminopyridine (200 mg) in pyridine (25 ml) was added dimethylcarbamoyl chloride (0.95 ml, 0.01 mmole). After stirring for 18 hours additional dimethylcarbamoyl chloride (1.5 ml) was added and stirring was continued for 18 hours. The reaction mixture was poured into ice water and excess hydrochloric acid to give 2.3 g of (2-sulfamoyl-6-benzothiazolyl) N,N-dimethylcarbamate which melts at 208°-209° C. after recrystallization from 2-propanol.

後処理

  1. additionwas added

出典と根拠

ORDレコード
ord-33a5ebb4954e46929f019ad73b6f61d9
出典データセット
uspto-grants-1984_09
特許番号
US04472417

反応ノート

読み込み中…