Acetophenone → Ethyl 2-(2-Butyl)-3-hydroxy-3-methyl-3-phenylpropionate

HRID 2418631

反応式

HRID 2418631 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[CH3:10][CH:11]([CH2:18][CH3:19])[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]>>[CH3:10][CH:11]([CH:12]([C:1]([OH:3])([CH3:2])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:18][CH3:19]

参加物

3

反応物 2

HCID 7410AcetophenoneHCID 560255Ethyl 3-methylpentanoate

生成物 1

HCID 13742288Ethyl 2-(2-Butyl)-3-hydroxy-3-methyl-3-phenylpropionate収率 36%

実験手順

The reaction of acetophenone (12 grams, 0.1 mole) with the enolate of ethyl 3-methylvalerate (14.4 grams, 0.1 mole) is carried out in the manner described in Example I. Distillation yields 9.5 grams (36%) of the pure product, b.p. 75°-80° C. (air bath temperature) at 0.05 mm Hg. I.R., N.M.R. and M.S. data confirm the above structure.

後処理

  1. distillationDistillation

出典と根拠

ORDレコード
ord-b8b9398871194129b91d33b382191fdd
出典データセット
uspto-grants-1984_09
特許番号
US04473085

関連ノート

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