Sodium Hydroxide → 2-(Oxiran-2-yl)-2,3-dihydro-1,4-benzodioxine
反応式
Br[CH2:2][C:3]([CH:5]1[O:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[O:7][CH2:6]1)=[O:4].[BH4-].[Na+].[OH-].[Na+]>CO>[O:10]1[C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[O:7][CH2:6][CH:5]1[CH:3]1[O:4][CH2:2]1参加物
5
実験手順
The starting material is prepared as follows: To the solution of 42 g of 2-(2-bromoacetyl)-1,4-benzodioxan in 360 ml of methanol, 12 g of sodium borohydride are added while stirring and keeping the temperature below 10°. After five hours, the mixture is cooled to 0° and 13.2 g of sodium hydroxide in 150 ml of methanol are added and the mixture kept at -15° overnight. It is poured onto ice, extracted with diethyl ether, the extract washed with saturated aqueous sodium chloride, dried and evaporated, to yield the 1,4-benzodioxan-2-yl-ethyleneoxide.
後処理
- customThe starting material is prepared
- customthe temperature below 10°
- temperaturethe mixture is cooled to 0°
- waitthe mixture kept at -15° overnight
- additionIt is poured onto ice
- extractionextracted with diethyl ether
- washthe extract washed with saturated aqueous sodium chloride
- customdried
- customevaporated
出典と根拠
- ORDレコード
- ord-dc0508866aaa4c01a9355947b2ae509c
- 出典データセット
- uspto-grants-1978_08
- 特許番号
- US04104396
反応ノート
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