4-Methoxyphenol → HCID 59288362、化合物
反応式
[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[C:4]([CH:5]=O)[C:3]=1[OH:11].CO[C:14]1[CH:19]=CC(O)=C[CH:15]=1.C1N2CC[N:23](CC2)C1>C(#N)C=C>[F:10][C:8]1[CH:7]=[C:4]2[C:3](=[C:2]([F:1])[CH:9]=1)[O:11][CH2:15][C:14]([C:19]#[N:23])=[CH:5]2参加物
5
反応条件
- 温度
- 75 °C
実験手順
84 g (0.531 mol) of 3,5-difluorosalicylaldehyde are dissolved in 850 ml of acrylonitrile, 1 g (8 mmol) of p-methoxyphenol and 18 g (0.16 mol) of DABCO are added, and the mixture is heated overnight at 75° C. The batch is evaporated, the residue is taken up in dichloromethane, and the solution is filtered through silica gel, giving 6,8-difluoro-2H-chromene-3-carbonitrile, which is sufficiently pure for further reactions.
後処理
- customThe batch is evaporated
- filtrationthe solution is filtered through silica gel
出典と根拠
- ORDレコード
- ord-5d79a87995874f61a28cd05da4597ee0
- 出典データセット
- uspto-grants-2011_06
- 特許番号
- US07955664B2
反応ノート
読み込み中…