Hydrochloric Acid → 3-{4-[(4-{[(4-Isopropyl-1,3-thiazol-2-yl)(3-methylbutyl)amino]methyl}benzyl)oxy]phenyl}propanoic acid

HRID 2422318

反応式

HRID 2422318 の反応式
[CH:1]([C:4]1[N:5]=[C:6]([N:9]([CH2:15][C:16]2[CH:35]=[CH:34][C:19]([CH2:20][O:21][C:22]3[CH:27]=[CH:26][C:25]([CH2:28][CH2:29][C:30]([O:32]C)=[O:31])=[CH:24][CH:23]=3)=[CH:18][CH:17]=2)[CH2:10][CH2:11][CH:12]([CH3:14])[CH3:13])[S:7][CH:8]=1)([CH3:3])[CH3:2].O.Cl>CO.O1CCCC1.[OH-].[Na+]>[CH:1]([C:4]1[N:5]=[C:6]([N:9]([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([CH2:20][O:21][C:22]3[CH:23]=[CH:24][C:25]([CH2:28][CH2:29][C:30]([OH:32])=[O:31])=[CH:26][CH:27]=3)=[CH:34][CH:35]=2)[CH2:10][CH2:11][CH:12]([CH3:14])[CH3:13])[S:7][CH:8]=1)([CH3:2])[CH3:3]

参加物

7

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 57541858Methyl 3-{4-[(4-{[(4-isopropyl-1,3-thiazol-2-yl)(3-methylbutyl)amino]methyl}benzyl)oxy]phenyl}propanoate

生成物 1

HCID 575419723-{4-[(4-{[(4-Isopropyl-1,3-thiazol-2-yl)(3-methylbutyl)amino]methyl}benzyl)oxy]phenyl}propanoic acid収率 88.2%

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

Methyl 3-{4-[(4-{[(4-isopropyl-1,3-thiazol-2-yl)(3-methylbutyl)amino]methyl}benzyl)oxy]phenyl}propanoate (140 mg) was dissolved in a mixed solvent of methanol (2 mL) and tetrahydrofuran (2 mL), and 2N aqueous sodium hydroxide solution (2 mL) was added. The mixture was stirred at room temperature for 1 hr. The reaction mixture was poured into water, acidified with 1N aqueous hydrochloric acid solution, and extracted with ethyl acetate. The ethyl acetate layer was dried using Presep Dehydration tube (manufactured by Wako Pure Chemical Industries, Ltd.), and concentrated to give the title compound (120 mg, yield 88%) as a pale-yellow oil.

後処理

  1. additionwas added
  2. extractionextracted with ethyl acetate
  3. dry with materialThe ethyl acetate layer was dried
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-f348630301544a0b8549e069dd629342
出典データセット
uspto-grants-2011_06
特許番号
US07960369B2

関連ノート

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